Anti-angiogenic agents are biological drugs used for treatment of retinal neovascular degenerative diseases.In this study, we aimed at in-silico analysis of interaction of vascular endothelial growth factor A (VEGFA), the syil x5 price main mediator of angiogenesis, with binding domains of anti-angiogenic agents used for treatment of retinal diseas
The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia
Abstract Background The different physiological repertoire of CA3 and CA1 neurons in the hippocampus, as well as their differing behaviour after noxious stimuli are ultimately based upon differences in the expressed genome.We have compared CA3 and CA1 gene expression in the uninjured brain, and after cerebral ischemia using laser microdissection (L
Quantifying continental collision dynamics for Alpine-style orogens
When continents collide, the arrival of positively buoyant continental crust slows down subduction.This collision often leads to the detachment of earlier subducted oceanic lithosphere, which changes the subsequent dynamics of the orogenic system.Recent studies of continental collision infer that the remaining slab may drive convergence through sla
Extinction Chains Reveal Intermediate Phases Between the Safety and Collapse in Mutualistic Ecosystems
Ecosystems are undergoing unprecedented persistent deterioration due to unsustainable anthropogenic human activities, such as overfishing and deforestation, and the effects of such damage on ecological stability are uncertain.Despite recent advances in experimental and theoretical studies on regime shifts and tipping points, theoretical tools for u